I found that if I have left images in an Album which are no longer where the album thinks they are (renamed, deleted, moved) there then cam2pc will not open. When it scans the pics in the album, and they are not there, it spits the dummy. It used to just place an icon in its place. The cure is to change the album data file found to be at:
I drop on Notepad and edit it. I usually find it easier to just delete the album entry and recreate the album in cam2pc.
I hope this helps someone. I still consider it a good programe - worth the money by today's rip-off world - but sorrowfully unsupported.